The implementation plan for NOAA’s Stony Coral Tissue Loss Disease Response and Prevention Strategy provides key actions by NOAA and partners that would increase understanding of and response to the disease in the Atlantic and Caribbean region and prevent its spread to the Indo-Pacific. The implementation plan builds on the framework provided by the NOAA Strategy for Stony Coral Tissue Loss Disease Response and Prevention, released in November 2020. It presents a clear, specific plan of action that can be used to secure funding for key disease research, response, engagement, and prevention activities over the next five years (2022-2027). Recognizing that stony coral tissue loss disease will be present on U.S. coral reefs for the foreseeable future, the implementation plan highlights actions necessary to understand and address this threat to coral reefs over the long term.